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. 2016 Feb 24;10:825–839. doi: 10.2147/DDDT.S101900

Figure 4.

Figure 4

Three-dimensional response surfaces with contour plots below generated from the D-LSCD demonstrating the effect of ERL loading%, emulsifier HLB, talc percentage, and the dispersed phase volume on the particle size (A), angle of repose (B), production yield (C), encapsulation efficiency (D), loading capacity (E), initial release (F), and time for 85% of drug release (G).

Abbreviations: HLB, hydrophilic lipophilic balance; ERL, Eudragit RLPO; D-LSCD, Draper–Lin small composite design; X1, ERLloading percentage; X2, emulsifier HLB; X3, talc percentage; X4, dispersed phase volume; X1X2, X1X3, X1X4, X2X3, X2X4, and X3X4 are the interaction terms between the factors; X1X1, X2X2, X3X3, and X4X4 are the quadratic terms between the factors; Y1, particle size; Y2, angle of repose; Y3, production yield; Y4, encapsulation efficiency; Y5, loading capacity; Y6, initial release; Y7, time for 85% of drug release.