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. Author manuscript; available in PMC: 2017 Jan 30.
Published in final edited form as: J Neurosci Methods. 2015 Oct 23;258:46–55. doi: 10.1016/j.jneumeth.2015.10.007

Figure 7.

Figure 7

BBB integrity and BBB Leakage. a) Z-stack of 100 μm above the pia. Substantial BBB leakage can be observed as indicated by SR101 leakage. b) Z-stack of 100 μm below the pia. Intravascular SR101 can be seen confined to the blood vessels and immediately adjacent to the probes, which also include additional vascular features. c) 3D-reconstruction side view emphasizes that BBB leakage is predominately above the brain and leakage is relatively dramatically reduced in the tissue.