Table 1.
Cohort characteristics
| Parameter | Total n=278 | 2000–2007 n=168 | 2008–2012 n=110 | p value | |
|---|---|---|---|---|---|
| Age in years | Median (IQR) | 69.3 (60.3–75.7) | 70.1 (59.8–75.4) | 68.6 (60.6–77.3) | 0.93 |
| Female sex, n (%) | 59 (21.2) | 36 (21.4) | 23 (20.9) | 0.92 | |
| Heavy Smoking (≥30pck-yrs), n (%) | 101 (36.3) | 63 (37.5) | 38 (34.6) | 0.62 | |
| Hydronephrosis, n (%) | 87 (31.3) | 49 (29.2) | 38 (34.6) | 0.34 | |
| Concurrent CIS, n (%) | 107 (38.5) | 66 (39.3) | 41 (37.3) | 0.74 | |
| cT-stage, n (%) | cTa/Tis/T1/T2 | 222 (79.9) | 131 (78.0) | 91 (82.7) | 0.33 |
| cT3/T4 | 56 (20.1) | 37 (22.0) | 19 (17.3) | ||
| cN-stage, n (%) | cN0 | 176 (63.3) | 92 (54.8) | 84 (76.4) | <0.001 |
| cN1+ | 53 (19.1) | 35 (20.8) | 18 (16.4) | ||
| cNx | 49 (17.6) | 41 (24.4) | 8 (7.3) | ||
| pT-stage, n (%) | pT0 | 16 (5.8) | 10 (6.0) | 6 (5.4) | 0.65 |
| pTa/Tis/T1/T2 | 97 (34.9) | 55 (32.7) | 42 (38.2) | ||
| pT3/T4 | 165 (59.3) | 103 (61.3) | 62 (56.4) | ||
| pN-stage, n (%) | pN0 | 163 (58.6) | 98 (58.3) | 65 (59.1) | 0.30 |
| pN-pos | 107 (38.5) | 63 (37.5) | 44 (40.0) | ||
| pNx | 8 (2.9) | 7 (4.2) | 1 (0.9) | ||
| Positive surgical margin*, n (%) | 18 (6.5) | 10 (6.0) | 8 (7.3) | 0.66 | |
| Node total, median (IQR) | 13.5 (8–20) | 13 (8–20) | 14 (9–20) | 0.39 |
Demographic and clinical characteristics of patients undergoing radical cystectomy between July 1st 2000 and June 30th 2013 compared before and after the initiation of the MDBCC in 2008;
*
Positive surgical margins are based on permanent sections (paraffin-embedded). Ureteral CIS was not counted as a positive margin; CIS: carcinoma in-situ; MDBCC: multidisciplinary bladder cancer clinic, Std diff : standardized difference.