Table 3. Differences in the effect of antihypertertensive drug therapy on systolic blood pressure in Users^* and Non-users.^† .

	Total	Beta blockers	Diuretics	ACE inhibitors	Calcium channel blockers
Change in systolic blood pressure‡ (mmHg)
User*§	-24.2 ± 18.9	-27.3 ± 20.9	-18.8 ± 17.9	-22.4 ± 17.4	-26.3 ± 19.3
Non-user†§	-26.2 ± 19.3	-27.8 ± 19.6	-24.4 ± 16.6	-24.6 ± 19.5	-29.6 ± 18.1
Difference in the change in systolic blood pressure (mmHg)
crude	1.98	0.45	5.62	2.19	3.30
(95% CI)	(-0.53, 4.48)	(-4.30, 5.20)	(-4.47, 15.71)	(1.24, 5.63)	(-3.52, 10.12)
adjusted||	2.88	0.37	6.11	3.85	3.50
(95% CI)	(0.89, 4.87)	(-3.24, 3.98)	(-3.16, 15.37)	(1.16, 6.66)	(-2.03, 9.02)

ACE: inhibitors: angiotensin-converting enzyme inhibitors

CI: confidence interval

* : Those co-administered antihypertensive and nonsteroidal anti-inflammatory drugs

† : Those not co-administered antihypertensive and nonsteroidal anti-inflammatory drugs

‡ : Change in the baseline systolic blood pressure after 2 months

§ : Mean ± standard deviation

|| : Adjusted for sex, age, classification of hypertension by extent of organ damage baseline systolic blood pressure, Drug Use Investigation, the use of medications that influence hypertension, and complications