Table 3. Changes in the outcome variables in each haplotype group.

	Number of TATG Haplotype
	0 (Hap0)		1 (Hap1)		2 (Hap2)
	Folic acid group	Placebo group	Folic acid group	Placebo group	Folic acid group	Placebo group
	(n = 35)	(n = 35)	(n = 49)	(n = 49)	(n = 17)	(n = 17)
Change in plasma homocysteine (µmol/L) †
After 1 month	-2.67 (2.29)**	-0.40 (1.65)	-2.60 (1.68)**	-1.02 (1.18)	-6.61 (6.42)	-2.09 (6.96)
After 3 months	-3.13 (2.13)**	-0.90 (1.51)	-2.82 (1.27)**	-0.83 (1.40)	-6.84 (8.42)*	4.87 (16.2)
Change in serum folic acid (ng/mL) †
After 1 month	12.9 (5.35)**	0.23 (2.25)	11.5 (6.4)**	-0.08 (4.23)	9.51 (6.67)**	0.16 (1.33)
After 3 months	13.5 (4.47)**	-0.38 (2.45)	15.0 (4.84)**	-1.19 (4.74)	11.07 (6.54)**	-0.49 (2.22)

† mean (SD) is indicated.

** p< 0.01 and *p < 0.05 for t test versus placebo group.

Changes are evaluated from the baseline level in each group.