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. 2015 Dec 10;21(2):55–70. doi: 10.1007/s12199-015-0498-7

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Lowered adaptive cerebral angiogenesis after exposure to hypoxia in transgenic mice expressing RNF213 R4757K in endothelial cells. a Several lines of transgenic or knockout or wild-type mice were exposed to hypoxia for 2 weeks at 8 % oxygen. Cerebral angiogenesis was evaluated by immunostaining Glut4. b Adaptive cerebral angiogenesis was abolished in transgenic mice overexpressing RNF213 R4757K (Human allelic ortholog of R4810K) in ECs, while in other mice adaptive angiogenesis was observed. Cited from Kobayashi et al. [21]