Table 2.

Relevant publications assessing human T cell immunity toward avian H5N1 and H7N9 influenza viruses.

Reference	Avian influenza subtype	T cells	Responses toward avian viruses
Jameson et al. (119)	H5N1	CTLs reactive to H1N1, H2N2, and H3N2, obtained from healthy individuals from USA	Cross-reactivity with H5N1
Lee et al. (122)	H5N1	CTLs reactive to H3N2 obtained from healthy individuals from Vietnam and UK	Cross-reactivity with H5N1
Goy et al. (120)	H5N1	CTLs reactive to H1N1 and H3N2 obtained from healthy individuals from Australia	Cross-reactivity with H5N1
Kreijtz et al. (121)	H5N1	In vitro expanded CTLs toward H3N2 obtained from healthy HLA-typed donors from the Netherlands	Cross-reactivity with H5N1-infected BLCL
van de Sandt et al. (123)	H7N9	CTLs expanded in vitro toward H1N1 (seasonal and pandemic) or H3N2 (seasonal) from healthy HLA-typed donors from the Netherlands	CTL cross-reactivity with H7N9-peptide loaded BLCLs
Quinones-Parra et al. (124)	H7N9	In vitro peptide-expanded PBMCs obtained from healthy HLA-typed individuals from Australia	CTL cross-reactivity with H7N9-derived immunogenic peptides is restricted by certain HLA haplotypes and varies across ethnicities
Chen et al. (20)	H7N9	PBMCs obtained from H7N9-infected patients in China	High numbers of peripheral blood T lymphocytes (CD4+ and CD8+) correlate with better clinical outcomes
Wang et al. (22)	H7N9	Ex vivo longitudinal analyses of PBMCs obtained from hospitalized H7N9-infected patients in Shanghai, China	Rapid recovery from H7N9 infection is associated with early CD8+ T cell responses