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. 2016 Mar 1;7:39. doi: 10.3389/fphar.2016.00039

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Copyright © 2016 Ghovanloo, Abdelsayed and Ruben.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative normalized current traces of INa_L. (A–H) Each panel shows the INa_L in Na_V1.5 or ΔKPQ before and after the perfusion of either 0.5 or 2.5 μM AMD or DES. Black curves represent control (0 μM drug solution), orange curves represent AMD at either 0.5 or 2.5 μM, and blue curves represent DES at either 0.5 or 2.5 μM.