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. 2015 Nov 15;594(5):1295–1310. doi: 10.1113/JP271066

Table 4.

Top 10 gene ontology biological processes that were significantly overrepresented in the kidney cortex during acute hypoxic stress, with or without ketamine

No. of Adjusted
Group Biological process genes involved P values
Hypoxia upregulated Immune response 108 1.13E‐31
Immune system process 133 1.11E‐26
Defense response 101 4.53E‐26
Inflammatory response 62 1.82E‐22
Regulation of immune system process 82 1.10E‐21
Response to other organism 63 5.05E‐19
Innate immune response 60 1.01E‐18
Response to biotic stimulus 63 5.32E‐18
Regulation of defense response 52 7.66E‐18
Regulation of response to stimulus 136 8.40E‐18
Hypoxia downregulated Cellular macromolecule metabolic process 461 2.13 E‐09
Macromolecule metabolic process 483 1.92 E‐07
Nucleic acid metabolic process 322 1.92 E‐07
Chromosome organization 78 1.92 E‐07
Regulation of macromolecule metabolic process 305 1.83 E‐07
Cellular component organization 302 1.83E‐07
Cellular component organization at cellular level 256 1.68 E‐07
Regulation of nitrogen compound metabolic process 266 1.68 E‐07
Peptidyl‐lysine acetylation 26 1.68 E‐07
Regulation of nucleobase‐containing compound metabolic process 263 1.12 E‐07
Hypoxia + ketamine upregulated Cellular macromolecule metabolic process 129 2.44 E‐02
Response to DNA damage stimulus 23 2.44 E‐02
Organelle organization 51 4.44 E‐02
Chromosome organization 23 4.44 E‐02
Double‐strand break repair 8 4.44 E‐02
DNA‐dependent DNA replication 8 4.26 E‐02
Cell cycle checkpoint 12 5.71 E‐02
Cellular protein metabolic process 69 5.83 E‐02
S phase 9 5.83 E‐02
Proteasome regulatory particle assembly 2 5.83 E‐02
Hypoxia + ketamine downregulated Negative regulation of biological process 92 1.07 E‐13
Negative regulation of cellular process 87 1.07 E‐13
Vasculature development 34 2.59 E‐12
Response to lipopolysaccharide 23 2.59 E‐12
Blood vessel development 33 2.71 E‐12
Blood vessel morphogenesis 31 2.80 E‐12
Response to molecule of bacterial origin 23 5.43 E‐12
Positive regulation of biological process 92 1.24 E‐11
Angiogenesis 27 3.28 E‐11
Response to chemical stimulus 79 5.06 E‐11