Table 4.
Top 10 gene ontology biological processes that were significantly overrepresented in the kidney cortex during acute hypoxic stress, with or without ketamine
No. of | Adjusted | ||
---|---|---|---|
Group | Biological process | genes involved | P values |
Hypoxia upregulated | Immune response | 108 | 1.13E‐31 |
Immune system process | 133 | 1.11E‐26 | |
Defense response | 101 | 4.53E‐26 | |
Inflammatory response | 62 | 1.82E‐22 | |
Regulation of immune system process | 82 | 1.10E‐21 | |
Response to other organism | 63 | 5.05E‐19 | |
Innate immune response | 60 | 1.01E‐18 | |
Response to biotic stimulus | 63 | 5.32E‐18 | |
Regulation of defense response | 52 | 7.66E‐18 | |
Regulation of response to stimulus | 136 | 8.40E‐18 | |
Hypoxia downregulated | Cellular macromolecule metabolic process | 461 | 2.13 E‐09 |
Macromolecule metabolic process | 483 | 1.92 E‐07 | |
Nucleic acid metabolic process | 322 | 1.92 E‐07 | |
Chromosome organization | 78 | 1.92 E‐07 | |
Regulation of macromolecule metabolic process | 305 | 1.83 E‐07 | |
Cellular component organization | 302 | 1.83E‐07 | |
Cellular component organization at cellular level | 256 | 1.68 E‐07 | |
Regulation of nitrogen compound metabolic process | 266 | 1.68 E‐07 | |
Peptidyl‐lysine acetylation | 26 | 1.68 E‐07 | |
Regulation of nucleobase‐containing compound metabolic process | 263 | 1.12 E‐07 | |
Hypoxia + ketamine upregulated | Cellular macromolecule metabolic process | 129 | 2.44 E‐02 |
Response to DNA damage stimulus | 23 | 2.44 E‐02 | |
Organelle organization | 51 | 4.44 E‐02 | |
Chromosome organization | 23 | 4.44 E‐02 | |
Double‐strand break repair | 8 | 4.44 E‐02 | |
DNA‐dependent DNA replication | 8 | 4.26 E‐02 | |
Cell cycle checkpoint | 12 | 5.71 E‐02 | |
Cellular protein metabolic process | 69 | 5.83 E‐02 | |
S phase | 9 | 5.83 E‐02 | |
Proteasome regulatory particle assembly | 2 | 5.83 E‐02 | |
Hypoxia + ketamine downregulated | Negative regulation of biological process | 92 | 1.07 E‐13 |
Negative regulation of cellular process | 87 | 1.07 E‐13 | |
Vasculature development | 34 | 2.59 E‐12 | |
Response to lipopolysaccharide | 23 | 2.59 E‐12 | |
Blood vessel development | 33 | 2.71 E‐12 | |
Blood vessel morphogenesis | 31 | 2.80 E‐12 | |
Response to molecule of bacterial origin | 23 | 5.43 E‐12 | |
Positive regulation of biological process | 92 | 1.24 E‐11 | |
Angiogenesis | 27 | 3.28 E‐11 | |
Response to chemical stimulus | 79 | 5.06 E‐11 |