Table 6.
Top 10 gene ontology biological processes and enriched KEGG pathways that were significantly upregulated in the kidney cortex during acute hypoxic stress, but were significantly downregulated with hypoxia + ketamine
| Analysis | Pathways, processes, functions, components | No. of genes involved | Adjusted P values |
|---|---|---|---|
| KEGG pathways | Osteoclast differentiation | 23 | 3.39E‐20 |
| Cytokine–cytokine receptor interaction | 30 | 3.39E‐20 | |
| Toll‐like receptor signalling pathway | 21 | 7.00E‐20 | |
| Chagas disease (American trypanosomiasis) | 18 | 1.08E‐15 | |
| NOD‐like receptor signalling pathway | 14 | 2.06E‐14 | |
| Malaria | 13 | 8.56E‐14 | |
| MAPK signalling pathway | 23 | 1.96E‐13 | |
| Cytosolic DNA‐sensing pathway | 13 | 2.43E‐13 | |
| Rheumatoid arthritis | 15 | 4.55E‐13 | |
| Chemokine signalling pathway | 19 | 1.69E‐12 | |
| Biological process | Negative regulation of biological process | 56 | 5.55E‐13 |
| Negative regulation of cell communication | 25 | 1.31E‐10 | |
| Negative regulation of cellular process | 54 | 5.52E‐13 | |
| Negative regulation of response to stimulus | 28 | 2.03E‐11 | |
| Negative regulation of signal transduction | 24 | 2.25E‐10 | |
| Negative regulation of signalling | 25 | 1.31E‐10 | |
| Regulation of cell communication | 42 | 1.09E‐10 | |
| Regulation of response to stimulus | 46 | 3.32E‐11 | |
| Regulation of signal transduction | 39 | 1.31E‐10 | |
| Regulation of signalling | 42 | 1.09E‐10 | |
| Molecular function | Protein binding | 72 | 4.08E‐07 |
| Cytokine receptor binding | 11 | 5.41E‐06 | |
| Cytokine activity | 9 | 2.00E‐04 | |
| Nucleic acid binding transcription factor activity | 19 | 3.00E‐04 | |
| Sequence‐specific DNA binding transcription factor activity | 19 | 3.00E‐04 | |
| Regulatory region DNA binding | 10 | 8.00E‐04 | |
| Regulatory region nucleic acid binding | 10 | 8.00E‐04 | |
| Interleukin‐1 receptor binding | 3 | 1.00E‐03 | |
| Sequence‐specific DNA binding | 14 | 1.00E‐03 | |
| RNA polymerase II core promoter proximal region sequence‐specific DNA binding transcription factor activity | 5 | 2.70E‐03 | |
| Cellular component | Cytosol | 31 | 2.00E‐04 |
| IκB–NFκB complex | 3 | 2.00E‐04 | |
| Extracellular space | 15 | 3.00E‐03 | |
| Cell surface | 10 | 9.80E‐03 | |
| Extracellular region part | 16 | 9.80E‐03 | |
| External side of plasma membrane | 6 | 2.03E‐02 | |
| Nucleus | 48 | 2.09E‐02 | |
| Intracellular part | 81 | 2.29E‐02 | |
| Intracellular | 82 | 2.98E‐02 | |
| Membrane‐bounded organelle | 67 | 3.05E‐02 |