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. 2016 Feb 29;594(5):1247–1264. doi: 10.1113/JP271091

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© 2016 The Authors. Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Values are mean ± SEM for pregnant sheep undergoing normoxic (◯, n = 6) or chronic hypoxic (, n = 6) pregnancy. Maternal blood gas values were corrected to 38 °C. pH, arterial pH; $P_{aC O_{2}}$ , arterial CO₂ partial pressure; $P_{a O_{2}}$ , arterial O₂ partial pressure; Sat[Hb], percentage saturation of haemoglobin; ABE, acid base excess; Htc, haematocrit; Glucose, blood glucose concentration; Lactate, blood lactate concentration; (N), normoxic recovery. The x‐axis shows time in hours (hr) and days (d). Significant differences (P < 0.05): *differences indicating a significant main effect of time compared with baseline; ^†differences indicating a significant main effect of treatment compared with normoxic pregnancy (two‐way repeated‐measures ANOVA + Tukey test). For Htc, the comparison of slopes was achieved with the Student's t test for unpaired data.

Inline graphic — Values are mean ± SEM for pregnant sheep undergoing normoxic (◯, n = 6) or chronic hypoxic (, n = 6) pregnancy. Maternal blood gas values were corrected to 38 °C. pH, arterial pH; $P_{aC O_{2}}$ , arterial CO₂ partial pressure; $P_{a O_{2}}$ , arterial O₂ partial pressure; Sat[Hb], percentage saturation of haemoglobin; ABE, acid base excess; Htc, haematocrit; Glucose, blood glucose concentration; Lactate, blood lactate concentration; (N), normoxic recovery. The x‐axis shows time in hours (hr) and days (d). Significant differences (P < 0.05): *differences indicating a significant main effect of time compared with baseline; ^†differences indicating a significant main effect of treatment compared with normoxic pregnancy (two‐way repeated‐measures ANOVA + Tukey test). For Htc, the comparison of slopes was achieved with the Student's t test for unpaired data.