Table 1.

Variables used to calculate oxygen and glucose delivery in the chronically hypoxic fetus

	Descending aortic		Descending aortic		Ascending aortic		Ascending aortic
	O2 content		blood glucose		O2 content		blood glucose		Carotid blood flow		Femoral blood flow
	(mmol l −1)		(mmol l−1)		(mmol l−1)		(mmol l−1)		(ml min−1)		(ml min−1)
	N	H	N	H	N	H	N	H	N	H	N	H
Experi‐
mental
day
−3	2.81 ± 0.08	3.20 ± 0.24	0.89 ± 0.17	0.86 ± 0.03	3.17 ± 0.13	3.90 ± 0.19	0.97 ± 0.26	0.91 ± 0.04	68.8 ± 13.8	69.7 ± 2.4	30.8 ± 4.6	32.0 ± 2.9
−2	2.93 ± 0.22	3.17 ± 0.19	0.90 ± 0.11	0.89 ± 0.08	3.23 ± 0.18	3.25 ± 0.05	0.83 ± 0.20	0.85 ± 0.05	71.7 ± 10.4	81.2 ± 4.0	29.6 ± 3.8	36.1 ± 3.4
−1	3.14 ± 0.12	3.30 ± 0.07	0.83 ± 0.15	1.20 ± 0.12	3.17 ± 0.14	3.59 ± 0.07	0.98 ± 0.12	1.17 ± 0.12	72.8 ± 9.1	74.3 ± 5.3	28.5 ± 0.6	36.1 ± 3.4
(−1 h)	2.89 ± 0.44	3.42 ± 0.20	0.72 ± 0.13	0.98 ± 0.11	3.17 ± 0.38	3.65 ± 0.22	0.83 ± 0.07	0.96 ± 0.11	69.7 ± 10.8	81.4 ± 7.1	35.9 ± 0.0	37.3 ± 1.9
(+6 h)	2.89 ± 0.41	1.82 ± 0.24*†	0.78 ± 0.10	1.02 ± 0.07	3.39 ± 0.47	1.91 ± 0.21*†	0.79 ± 0.09	1.04 ± 0.10	68.2 ± 12.3	104.1 ± 7.5*	35.5 ± 0.4	44.3 ± 4.1
(+24 h)	2.93 ± 0.50	1.63 ± 0.31*†	0.76 ± 0.16	0.97 ± 0.08	3.34 ± 0.43	1.89 ± 0.32*†	0.73 ± 0.10	0.98 ± 0.10	64.5 ± 8.9	96.8 ± 9.9	33.1 ± 1.2	47.1 ± 3.2*
2	2.81 ± 0.19	2.08 ± 0.38*	0.82 ± 0.14	0.92 ± 0.08	3.21 ± 0.15	2.01 ± 0.26*†	0.76 ± 0.11	0.86 ± 0.09	76.9 ± 11.8	90.9 ± 10.7†	35.8 ± 1.1	40.8 ± 3.0*†
3	3.05 ± 0.17	2.25 ± 0.37*	0.79 ± 0.09	1.03 ± 0.15	3.54 ± 0.15	2.51 ± 0.27*†	0.82 ± 0.10	0.96 ± 0.14	78.2 ± 8.2	86.2 ± 12.1†	33.8 ± 3.0	36.2 ± 1.1†
4	3.03 ± 0.22	2.17 ± 0.30*†	0.77 ± 0.18	0.98 ± 0.03	3.49 ± 0.19	2.56 ± 0.24*†	0.70 ± 0.15	0.89 ± 0.05	74.8 ± 7.7	104.4 ± 11.7*	36.0 ± 3.6	45.6 ± 3.6†
5	3.22 ± 0.41	1.89 ± 0.39*†	0.67 ± 0.16	0.84 ± 0.08	3.52 ± 0.20	2.01 ± 0.32*†	0.72 ± 0.12	0.79 ± 0.07	69.3 ± 6.0	96.4 ± 11.6*	35.4 ± 4.3	43.3 ± 1.5
6	3.01 ± 0.41	2.16 ± 0.35*	0.61 ± 0.09	0.92 ± 0.04	3.45 ± 0.29	2.44 ± 0.38*†	0.73 ± 0.09	0.96 ± 0.06	77.3 ± 7.1	88.2 ± 11.5*	35.9 ± 5.1	38.8 ± 2.3†
7	2.74 ± 0.25	2.64 ± 0.35*	0.72 ± 0.15	0.89 ± 0.08	3.03 ± 0.10	2.81 ± 0.35	0.73 ± 0.16	0.91 ± 0.11	82.2 ± 10.0	103.7 ± 14.6	38.9 ± 4.8	40.8 ± 1.9
8	3.20 ± 0.38	1.62 ± 0.17*†	0.82 ± 0.10	0.90 ± 0.11	3.33 ± 0.42	1.79 ± 0.12*†	0.77 ± 0.15	0.92 ± 0.11	81.9 ± 7.8	101.4 ± 7.7*	44.2 ± 1.2	43.2 ± 1.9
9	2.86 ± 0.09	2.27 ± 0.40*	0.80 ± 0.11	0.78 ± 0.11	3.29 ± 0.16	2.67 ± 0.20*	0.69 ± 0.13	0.84 ± 0.09	93.0 ± 12.7	82.4 ± 11.6*	45.4 ± 3.3*	35.7 ± 1.7
10	2.73 ± 0.11	2.56 ± 0.54*	0.72 ± 0.15	0.81 ± 0.07	3.40 ± 0.04	2.92 ± 0.61*	0.85 ± 0.16	0.84 ± 0.08	90.2 ± 10.1	94.9 ± 8.3	37.0 ± 1.2*	39.5 ± 1.8
11	3.11 ± 0.21	2.30 ± 0.16*†	0.62 ± 0.10	0.79 ± 0.04	3.26 ± 0.27	2.69 ± 0.29*	0.80 ± 0.15	0.82 ± 0.07	82.5 ± 5.4	101.3 ± 12.6*	36.2 ± 1.3	39.9 ± 7.2
12(N)	3.03 ± 0.20	4.40 ± 0.19†	0.69 ± 0.11	0.62 ± 0.04	3.35 ± 0.17	4.58 ± 0.18†	0.86 ± 0.17	0.65 ± 0.05	83.2 ± 10.3	85.3 ± 7.2*	36.8 ± 1.0	29.7 ± 3.7†
13(N)	2.64 ± 0.17	4.35 ± 0.38†	0.69 ± 0.12	0.80 ± 0.06	2.70 ± 0.12	4.82 ± 0.25	0.66 ± 0.13	0.76 ± 0.03	101.8 ± 16.2*	92.9 ± 9.7*	37.1 ± 2.3	30.1 ± 0.7

Values are mean ± SEM variables required to calculate oxygen and glucose delivery throughout the experimental protocol. Data are shown for fetal ascending and descending arterial oxygen content, blood glucose and flows in normoxic (N) and hypoxic (H) fetuses (n = 6 both groups). Significant differences (P < 0.05): *differences indicating a significant main effect of time compared with baseline; †differences indicating a significant main effect of treatment compared with normoxic pregnancy (two‐way repeated‐measures ANOVA + Tukey test).