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Amelioration of cardiomyopathy by exercise training. Hyperglycemia induces overexpression of cytoplasmic subunits of NADH oxidase (p47phox and p67phox) in left ventricle. Overexpression of these subunits exhibits high reactive oxygen species and leads to increased collagen III and hence cardiomyopathy. Exercise training (ExT) mitigates the expression of p47phox, and p67phox consequently ameliorates heart dysfunctions.
