Table 4.
Genetic risk factors for cleft palate.
| Study | Country | SNP/nearby gene(s) (chromosome) | OR (95% CI) or p-value |
|---|---|---|---|
| LINKAGE STUDIES | |||
| Koillinen et al., 2005 | Finland | 1p34 | p = 0.069 |
| 2p24-p25 | p = 0.016 | ||
| 12q21 | p < 0.05 | ||
| ASSOCIATION STUDIES | |||
| Pan et al., 2013 | China | rs742071 (1p36) | 0.85 (0.36–2.03) |
| rs7590268 (2p21) | 2.05 (1.07–3.91) | ||
| rs7632427 (3p11.1) | 1.00 (0.61–1.64) | ||
| rs12543318 (8q21.3) | 1.02 (0.68–1.52) | ||
| rs8001641 (13q31.1) | 1.52 (0.95–2.43) | ||
| rs1873147 (15q22.2) | 0.41 (0.20–0.86) | ||
| Butali et al., 2014b | Africa | c.493C > G (20q12) | Not listed |
| Nikopensius et al., 2010 | Estonia | rs17389541 (1q32.3-q41) | 1.726 (1.263–2.358) |
| Latvia | rs1793949 (12q13.11) | 1.659 (1.235–2.229) | |
| Lithuania | rs11653738 (17q21) | 1.518 (1.123–2.053) | |
| Carter et al., 2010 | Ireland | rs3769817 (2q33.1) | 1.45 (1.06–1.99) |
| rs2166975 (2p13.3) | p = 0.041 | ||
| Ghassibe-Sabbagh et al., 2011 | Europe, USA Philippines | rs3827730 (1p32.3) | p = 0.0003 |