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. 2016 Feb 16;14(2):36. doi: 10.3390/md14020036

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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ATX-produced membrane depolarization was dependent on the activation of hNa_v1.7. (A) TTX antagonized ATX-induced membrane depolarization in hNa_v1.7 HEK-293 cells as a function of time; (B) Concentration-response curve for TTX suppressed ATX-induced depolarization in hNa_v1.7 HEK 293 cells. Each data point represents the mean ± SEM from two independent cultures performed in triplicate; (C) and (D) ATX response on membrane depolarization in hNa_v1.7-HEK-293 cells and null HEK-293 cells as a function of time, respectively; (E) Concentration-response relationships of ATX response on membrane depolarization in hNa_v1.7-HEK-293 cells and null HEK-293 cells. This experiment was performed in two independent cultures, each in triplicate with similar results.