Table 2. Brain regions showing reduced grey matter volume in SLE patients when compared to healthy controls.
| Brain regions | L/R | At diagnosis (S1) |
After attaining low SLE activity (S2) |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| MNI Coordinates (mm) |
Analysis |
MNI Coordinates (mm) |
Analysis |
||||||||
| x | y | z | t-stats | size | x | y | z | t-stats | size | ||
| ORBinf/TPOmid | L | −30 | 21 | −35 | 6.56 | 177 | −26 | 18 | −24 | 6.50 | 70 |
| INS/ORBinf | R | 28 | 15 | −17 | 6.64 | 255 | 36 | 21 | −20 | 7.66 | 996 |
| IFGtri/INS | L | −27 | 30 | −2 | 6.83 | 203 | −32 | 30 | −3 | 6.71 | 146 |
| ITG | L | −42 | −12 | −29 | 6.96 | 119 | −56 | −67 | −18 | 6.50 | 54 |
| MCC | L | 12 | −12 | 49 | 7.82 | 443 | 14 | −10 | 51 | 7.27 | 436 |
| MFG/SFG | R | 20 | 53 | 3 | 7.67 | 231 | 21 | 53 | 3 | 7.31 | 180 |
| ORBmid | R | 22 | 68 | −11 | 7.07 | 611 | 22 | 68 | −12 | 6.91 | 97 |
| ROL/IFGoperc | R | 57 | 9 | 3 | 8.33 | 729 | 36 | 21 | −20 | 7.66 | 996 |
| LING | L | −16 | −57 | −8 | 6.55 | 109 | — | — | — | — | — |
| CB | L | −20 | −72 | −35 | 6.55 | 224 | — | — | — | — | — |
| IFGoperc/PreCG | L | −38 | 5 | 22 | 7.39 | 249 | — | — | — | — | — |
| IPL | L | −39 | −52 | 46 | 7.38 | 171 | — | — | — | — | — |
| TPO | R | 46 | 27 | −23 | 6.67 | 140 | — | — | — | — | — |
| MCC | R | 9 | −36 | 43 | 6.83 | 148 | |||||
| PreCG | L | −21 | −30 | 55 | 7.16 | 120 | |||||
| SFG | R | 22 | −6 | 51 | 6.67 | 61 | |||||
| PCL/PCUN | R | — | — | — | — | — | 10 | −39 | 57 | 6.92 | 120 |
| SMA/MCC | R | — | — | — | — | — | 10 | 14 | 48 | 7.28 | 227 |
| SMA/MCC | L | — | — | — | — | — | 14 | −10 | 51 | 7.27 | 436 |
| CUN/PCUN | R | — | — | — | — | — | 14 | −75 | 37 | 6.79 | 150 |
| MTG | R | — | — | — | — | — | 49 | −58 | 12 | 6.86 | 93 |
Regions having reduced GMV in SLE patients compared to healthy controls were reported at a height threshold of p < 0.01 family-wise error corrected with the minimum cluster size of 50 voxels (p < 0.05 extent threshold). S1: Regions of Interest (ROIs) having reduced GMV in SLE patients at diagnosis. S2: ROIs having reduced GMV in SLE patients after attaining low SLE disease activity. The t-stats and coordinates (x, y and z in mm) of the peak voxel within each cluster are given. The size of each cluster (number of voxels) are also provided (each voxel equals to 1.5 mm3).
Abbreviations: L = left, R = right, ORBinf = inferior frontal gyrus (orbital part), IFGtri = inferior frontal gyrus (triangular part), ITG = inferior temporal gyrus, MCC = middle cingulate cortex, MFG = middle frontal gyrus, ORBmid = middle frontal gyrus (orbital part), INS = insula, ROL = rolandic operculum, SFGdor = superior frontal gyrus (dorsolateral), LING = lingual gyrus, CB = cerebellum, TPO = temporal pole, IFGoperc = inferior frontal gyrus (opercular part), PreCG = precentral gyrus, IPL = inferior parietal, excluding supramarginal and angular gyri, PCL = paracentral lobule, PCUN = precuneus, SMA = supplementary motor area, CUN = cuneus, MTG = middle temporal gyrus.