Table 3. Brain regions showing reduced white matter volume in SLE patients when compared to healthy controls.

Brainregions	L/R	At diagnosis (S1)					After attaining low SLE activity (S2)
		MNI Coordinates (mm)			Analysis		MNI Coordinates (mm)			Analysis
		x	y	z	t-stats	size	x	y	z	t-stats	size
ATR	L	−14	38	38	6.93	488	−14	38	38	6.20	133
ATR	R	21	56	−9	6.98	549	21	57	12	6.34	238
CST	L	−8	−24	63	6.50	1335	−8	−24	63	6.19	219
CST	R	15	−20	53	6.52	1297	11	−30	66	6.11	733
CCG	L	−12	38	38	6.92	348	−9	38	39	6.28	147
CCG	R	12	11	41	6.27	364	12	14	39	6.31	300
FMN	L/R	−14	38	36	6.81	841	21	59	11	6.45	532
IFOF	L	−12	38	39	6.86	295	−11	38	39	6.23	126
IFOF	R	20	56	−9	6.97	811	20	56	−9	6.28	103
SLF	L	−14	36	39	6.80	1065	−23	−6	51	6.21	221
SLF	R	47	5	14	6.30	433	23	−39	56	6.00	110
FMJ	L/R	14	−93	0	6.69	1110	—	—	—	—	—
ILF	R	42	−57	−2	6.06	209	—	—	—	—	—
UF	L	−14	38	39	6.88	83	—	—	—	—	—
UF	R	23	54	−11	6.45	119	—	—	—	—	—

Regions having reduced WMV in SLE patients compared to healthy controls were reported at the height threshold of p < 0.05 family-wise error corrected with the minimum cluster size of 50 voxels (p < 0.05 extent threshold). S1: Controls versus SLE patients at diagnosis. S2: Controls versus SLE patients after sufficient disease control. The t-stats and coordinates (x, y and z in mm) of the peak voxel within each cluster are given. The size of each cluster (number of voxels) are also provided (each voxel equals to 1.5 mm³).

Abbreviations: L = left, R = right. ATR = anterior thalamic radiation, CST = corticospinal tract, CCG = cingulum cingulate gyrus, FMN = forceps minor, IFOF = inferior fronto-occipital fasciculus, SLF = superior longitudinal fasciculus, FMJ = forceps major, ILF = inferior longitudinal fasciculus, UF = ucinate fasciculus.