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. 2016 Mar 1;6:22096. doi: 10.1038/srep22096

Figure 5. Aged rats lacked learning-related changes in unmethylated PKMζ DNA.

Figure 5

(A) Baseline level of PKMζ DNA methylation in the PrL. *p < 0.05, compared with young group. n = 5 per experimental group. (B) Baseline level of PKMζ DNA methylation in the IL. *p < 0.05, compared with young group. n = 5 per experimental group. (C) Experimental timeline for detection of PKMζ DNA methylation and mRNA. (D) Levels of methylated and unmethylated PKMζ DNA in the PrL after conditioning training or footshock only. *p < 0.05, compared with manipulation-matched young group; #p < 0.05, compared with age-matched shock group. n = 6–7 per experimental condition. (E) Levels of methylated and unmethylated PKMζ DNA in the IL after conditioning training or footshock only. *p < 0.05, compared with manipulation-matched young group. n = 6–7 per experimental condition. (F) Level of PKMζ mRNA in the PrL after conditioning training or footshock only. *p < 0.05, compared with manipulation-matched young group. n = 6–7 per experimental condition. (G) Level of PKMζ mRNA in the IL after conditioning training or footshock only.