Table 1. Baseline characteristics of NPC patients with diabetes and prediabetes.
| Characteristics | Normoglycemia | Diabetes | P1 | Prediabetes | P2 |
|---|---|---|---|---|---|
| No. (%) | No. (%) | No. (%) | |||
| Total | 1240 | 81 | 168 | ||
| Age (years) | <0.001 | <0.001 | |||
| ≥50 | 354 (28.5) | 53 (65.4) | 94 (56.0) | ||
| <50 | 886 (71.5) | 28 (34.6) | 74 (44.0) | ||
| Gender | 0.561 | 0.176 | |||
| Male | 914 (73.7) | 64 (79.0) | 132 (78.6) | ||
| Female | 326 (26.3) | 17 (21.0) | 36 (21.4) | ||
| WHO pathology | 0.451 | 0.329 | |||
| Type I | 7 (0.6) | 1 (1.2) | 0 (0) | ||
| Type II/III | 1233 (99.4) | 80 (98.8) | 168 (100) | ||
| T classificationa | 0.2 | 0.724 | |||
| T1 + T2 | 423 (34.1) | 22 (27.2) | 55 (32.7) | ||
| T3 + T4 | 817 (65.9) | 59 (72.8) | 113 (67.3) | ||
| N classificationa | 0.423 | 0.319 | |||
| N0 + N1 | 937 (75.6) | 58 (71.6) | 121 (72.0) | ||
| N2 + N3 | 303 (24.4) | 23 (28.4) | 47 (28.0) | ||
| Overall stagea | 0.501 | 0.443 | |||
| I | 70 (5.6) | 2 (2.4) | 5 (3.0) | ||
| II | 259 (20.9) | 14 (17.3) | 40 (23.8) | ||
| III | 586 (47.3) | 42 (51.9) | 81 (48.2) | ||
| IVA-IVB | 325 (26.2) | 23 (28.4) | 42 (25.0) | ||
| Pre-DNA (copy/ml) | 0.036 | 0.434 | |||
| ≥1325 | 654 (52.7) | 33 (40.7) | 94 (56.0) | ||
| <1325 | 586 (47.3) | 48 (59.3) | 74 (44.0) | ||
| Smoking | 0.344 | 0.734 | |||
| Yes | 463 (37.3) | 26 (32.1) | 65 (38.7) | ||
| No | 777 (62.7) | 55 (67.9) | 103 (61.3) | ||
| Drinking | 0.195 | 0.009 | |||
| Yes | 170 (13.7) | 7 (8.6) | 11 (6.5) | ||
| No | 1070 (86.3) | 74 (91.4) | 157 (93.5) | ||
| CHO | 0.006 | <0.001 | |||
| ≥6.47 | 113 (9.1) | 15 (18.5) | 30 (17.9) | ||
| <6.47 | 1127 (90.9) | 66 (81.5) | 138 (82.1) | ||
| TG | 0.001 | <0.001 | |||
| ≥1.70 | 368 (29.7) | 41 (50.6) | 75 (44.6) | ||
| <1.70 | 872 (70.3) | 40 (49.4) | 93 (55.4) | ||
| LDL-C | 0.03 | 0.007 | |||
| ≥3.40 | 521 (42.0) | 44 (54.3) | 89 (53.0) | ||
| <3.40 | 719 (58.0) | 37 (45.7) | 79 (47.0) | ||
| HDL-C | 0.518 | 0.336 | |||
| ≥0.78 | 1211 (97.7) | 80 (98.8) | 162 (96.4) | ||
| <0.78 | 29 (2.3) | 1 (1.2) | 6 (3.6) | ||
| Hypertension | <0.001 | <0.001 | |||
| Yes | 86 (6.9) | 24 (29.6) | 28 (16.7) | ||
| No | 1154 (93.1) | 57 (70.4) | 140 (83.3) | ||
| Cardiovascular complications | <0.001 | <0.001 | |||
| Yes | 101 (8.1) | 25 (30.9) | 30 (17.9) | ||
| No | 1139 (91.9) | 56 (69.1) | 138 (82.1) | ||
| Chemotherapy | 0.714 | 0.647 | |||
| Yes | 1069 (86.2) | 71 (87.7) | 147 (87.5) | ||
| No | 171 (13.8) | 10 (12.3) | 21 (12.5) |
Abbreviations: WHO = World Health Organization; Pre-DNA = pre-treatment Epstein-Barr virus DNA; CHO = total cholesterol; TG = triglycerides; LDL-C = low density lipoprotein cholesterol; HDL-C = high density lipoprotein cholesterol.
aAccording to the 7th edition of the AJCC/UICC staging system.
P1: diabetes vs. normoglycemia; P2: prediabetes vs. normoglycemia.