Table 1.
List of identified mammalian selenoprotein genes and their known functions.
| Selenoprotein Gene | Abbreviation | Function(s) |
|---|---|---|
| 15 kDa-selenoprotein | Sep15 | Protein folding |
| Iodothrionine Deiodinase 1–3 | Dio1–3 | Thyroid hormone activity regulation |
| Glutathione Peroxidase 1–4, 6 | GPx1–6 | Hydroperoxide/phospholipid peroxide reduction |
| Methionine-R-Sulfoxide Reductase 1 | MsrB1 | Reduces oxidized methionine residues |
| Selenoprotein H | SelH | Genome maintenace |
| Selenoprotein I | SelI | Unknown |
| Selenoprotein K | SelK | ER-associated degradation; inflammation |
| Selenoprotein M | SelM | Ca2+ homeostasis |
| Selenoprotein N | SelN | Muscle development |
| Selenoprotein O | SelO | Unknown |
| Selenoprotein P | Sepp1 | Selenium transport |
| Selenoprotein S | SelS | ER-associated degradation; inflammation |
| Selenophosphate Synthase 2 | SPS2 | Selenoprotein biosynthesis |
| Selenoprotein T | SelT | Ca2+ homeostasis; neuroendocrine secretion |
| Thioredoxin Reducase 1–3 | TrxR1–3 | Disulfide bond reduction |
| Selenoprotein V | SelV | Unknown |
| Selenoprotein W | SelW | Unknown |