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. 2016 Feb 16;8(2):92. doi: 10.3390/nu8020092

Figure 3.

Figure 3

Effects of phlorizin on plasma adipokines (A); fibrosis of hepatic (B); and adipose tissue (C). C57BL/6J mice (n = 10/group) were fed experimental diets for 16 weeks. (A) Data are Mean ± Standard Error. Significant differences between HFD vs. ND are indicated: * p < 0.05, ** p < 0.01. Significant differences between HFD vs. PH are indicated: † p < 0.05, †† p < 0.01, ††† p < 0.001; (B,C) Masson’s trichrome stained transverse-section of liver and epididymal fat. Fibrillar collagens, primarily collagen I and III, are stained with blue as indicated with arrowheads. Nuclei and keratin are stained with deep purple and red, respectively. Original magnification (liver, 200×; adipose tissue, 400×). ND, normal diet (AIN-76); HFD, high-fat diet (20% fat, 1% cholesterol, w/w); PH, HFD with 0.02% phlorizin (w/w). TNF-α, tumor necrosis factor-alpha; MCP-1, monocyte chemoattractant protein-1; IFN-γ, interferon-gamma; IL-6, interleukin-6; WAT, white adipose tissue.