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. 2016 Mar;6(3):a022384. doi: 10.1101/cshperspect.a022384

Figure 1.

Figure 1.

Abnormal hyperpolarization-activated cyclic nucleotide-gated ion (HCN) channel regulation and assembly following seizures. HCN channel subunits consist of six transmembrane segments (top left). The cytoplasmic carboxyl terminus contains a 120-amino-acid cyclic nucleotide-binding domain (CNBD). HCN1 messenger RNA (mRNA) and protein levels are significantly reduced in the hippocampus following seizures in many animal models of epilepsy; HCN2 levels do not alter appreciably (top right). Altered HCN channel assembly following seizures may result from a reduction of HCN1 subunits (bottom). SF, Silencer factor; cAMP, cyclic adenosine 3′, 5′-monophosphate.