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. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Immunol. 2016 Feb 24;196(7):3180–3190. doi: 10.4049/jimmunol.1501435

Figure 6. B cell deficiency or depletion compromises homeostatic recovery of CD8 T cells.

Figure 6

A-B. B6.WT or B6.μMT mice were transplanted with BALB/c heart allografts and treated with mATG. Numbers of peripheral blood T cells (A) and heart allograft survival (B) were evaluated in 4-13 mice per group. *** p < 0.0001 for WT and μMT recipients treated with mATG. C-D. B6.huCD20tg mice were transplanted with BALB/c heart allografts, injected with mATG (days 0, 4) and either treated with Rituximab (Rtx, 0.5 mg i.p. every 5 days starting on day 0) or left untreated. Numbers of peripheral blood T cells (C) and heart allograft survival (D) were evaluated in 3-11 mice per group. ** p < 0.001 for recipients treated with mATG alone vs mATG + Rtx. E. mATG depletion was performed in naïve non-transplanted B6.WT and B6.mMT mice (top) or in naïve non-transplanted B6.huCD20tg mice with or without Rtx treatment (bottom).