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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Sci Signal. 2013 Jul 9;6(283):ra55. doi: 10.1126/scisignal.2003900

Fig. 1. Identification of G5-7 and its SAR.

Fig. 1

(A) Effect of 4539-B8 or 4544-G5 (1 μM for 96 hours) on the proliferation of U87MG/EGFRvIII and U87MG/PTEN cells. Data are means ± SEM [**P < 0.01, two-way analysis of variance (ANOVA), n = 3]. (B) SAR study of the G5-ethylester group (compounds G5-1 to G5-17) and their antiproliferative effect on U87MG/EGFRvIII and U87MG/PTEN cells. Data are means ± SEM (**P < 0.01, two-way ANOVA, n = 3). (C and D) Analysis of the antiproliferative effect of the G5-7 derivatives, (C) G5-phenylester group–containing compounds (G5-N) and (D) G5-alkyl group–containing compounds (G5-X), on U87MG/EGFRvIII cells compared with U87MG/PTEN cells. Data are means ± SEM (n = 3 experiments; **P < 0.01, two-way ANOVA, n = 3). (E) Synthetic route of G5-7 and G5-7-H.

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