Table 3.
The genotypic and allelic frequencies between the subjects with normal HDL-C and low HDL-C.
| SNPs | Control | Case | OR | 95% CI | p |
|---|---|---|---|---|---|
| rs2515602 | |||||
| CC n (%) | 47 (22.7) | 82 (40.2) | 1 | ||
| CT n (%) | 88 (42.5) | 84 (41.2) | 1.828 | 1.146–2.915 | 0.011 |
| TT n (%) | 72 (34.8) | 38 (18.6) | 3.306 | 1.942–5.627 | p < 0.001 |
| C allele n (%) | 182 (43.9) | 248 (60.8) | 1.976 | 1.497–2.608 | p < 0.001 |
| HWE-P | 0.377 | 0.35 | |||
| rs3890182 | |||||
| GG n (%) | 193 (93.2) | 183 (89.7) | 1 | ||
| AG n (%) | 12(5.8) | 21 (10.3) | 0.542 | 0.259–1.133 | 0.099 |
| AA n (%) | 2 (1.0) | - | - | - | - |
| G allele n (%) | 398 (96.1) | 387 (94.9) | 0.880 | 0.466 - 1.662 | 0.693 |
| HWE-P | 0.768 | 0.576 | |||
| rs2275542 | |||||
| CC n (%) | 110 (53.1) | 87 (42.6) | 1 | ||
| CT n (%) | 74 (35.7) | 96 (47.1) | 0.610 | 0.403–0.922 | 0.019 |
| TT n (%) | 23 (11.1) | 21 (10.3) | 0.866 | 0.450–1.668 | 0.667 |
| C allele n (%) | 294 (71.0) | 270 (66.2) | 0.799 | 0.594–1.073 | 0.135 |
| HWE-P | 0.374 | 0.905 | |||
| rs2230806 | |||||
| AA n (%) | 20 (9.7) | 44 (21.6) | 1 | ||
| AG n (%) | 89 (43.0) | 98 (48.0) | 1.998 | 1.095–3.646 | 0.023 |
| GG n (%) | 98 (47.3) | 62 (30.4) | 3.477 | 1.877–6.444 | p < 0.001 |
| A allele n (%) | 129 (31.2) | 186 (45.6) | 1.851 | 1.392–2.461 | p < 0.001 |
| HWE-P | 0.99 | 0.956 | |||
| rs1800976 | |||||
| CC n (%) | 41 (19.8) | 50 (24.5) | 1 | ||
| CG n (%) | 114 (55.1) | 91 (44.6) | 1.528 | 0.930–2.510 | 0.093 |
| GG n (%) | 52 (25.1) | 63 (30.9) | 1.007 | 0.579–1.749 | 0.981 |
| C allele n (%) | 196 (47.3) | 191 (46.8) | 0.979 | 0.744–1.287 | 0.879 |
| HWE-P | 0.556 | 0.609 | |||
| rs4149313 | |||||
| AA n (%) | 99 (47.8) | 64 (31.4) | 1 | ||
| AG n (%) | 84 (40.6) | 94 (46.1) | 0.578 | 0.376–0.889 | 0.012 |
| GG n (%) | 24 (11.6) | 46 (22.5) | 0.337 | 0.188–0.606 | p < 0.001 |
| A allele n (%) | 282 (68.1) | 222 (54.4) | 0.559 | 0.421–0.742 | p < 0.001 |
| HWE-P | 0.797 | 0.727 | |||
Note: HWE-P, Hardy-Weinberg equilibrium p value. Rs2515602-CC, rs3890182-GG, rs2275542-CC, rs2230806-AA, rs1800976-CC, and rs4149313-AA genotypes used as a reference genotype for obtaining the Odds Ratio calculations separated for each single nucleotide polymorphism.