Table 4.
The genotypes of six SNPs and serum lipid levels (mmol/L) between the subjects with normal HDL-C and low HDL-C.
| SNPs | Group | Genotype | n (%) | TG | TC | LDL-C | HDL-C |
|---|---|---|---|---|---|---|---|
| rs2515602 | control | CC | 47 (22.7) | 0.81 (0.56–1.22) | 3.98 (3.54–4.56) | 2.06 (1.69–2.34) | 1.35 (1.27–1.48) * |
| CT | 88 (42.5) | 0.89 (0.64–1.70) | 4.23 (3.63–4.79) | 2.11 (1.74–2.73) | 1.43 (1.31–1.59) | ||
| TT | 72 (34.8) | 0.82 (0.62–1.11) | 4.24 (3.55–4.80) | 2.01 (1.62–2.62) | 1.55 (1.36–1.71) * | ||
| case | CC | 82 (40.2) | 1.10 (0.79–1.59) * | 3.63 (3.07–4.31) | 1.92 (1.46–2.52) | 0.95 (0.87–0.99) | |
| CT | 84 (41.2) | 1.07 (0.71–1.54) * | 3.63 (2.54–4.18) * | 1.81 (1.27–2.38) * | 0.95 (0.83–0.99) | ||
| TT | 38 (18.6) | 1.46 (1.02–2.55) * | 4.05 (3.24–4.77) * | 2.11 (1.66–2.56) * | 0.95 (0.86–0.99) | ||
| rs3890182 | control | AA | 193 (93.2) | 0.83 (0.62–1.25) | 4.23 (3.59–4.79) | 2.08 (1.67–2.65) | 1.43 (1.31–1.64) |
| AG | 12 (5.8) | 0.77 (0.52–1.21) | 3.83 (3.47–4.60) | 1.95 (1.52–2.47) | 1.42 (1.29–1.50) | ||
| case | AA | 183 (89.7) | 1.14 (0.80–1.90) | 3.76 (3.04–4.39) | 1.96 (1.46–2.51) | 0.95 (0.84–0.99) | |
| AG | 21 (10.3) | 0.90 (0.67–1.33) | 3.29 (2.83–4.02) | 1.66 (1.36–2.32) | 0.97 (0.88–1.00) | ||
| rs2275542 | control | CC | 110 (53.1) | 0.81 (0.61–1.38) | 4.21 (3.49–4.85) | 2.09 (1.64–2.72) | 1.42 (1.30–1.60) * |
| CT | 74 (35.7) | 0.85 (0.64–1.24) | 4.22 (3.68–4.77) | 1.99 (1.65–2.61) | 1.42 (1.32–1.64) | ||
| TT | 23 (11.1) | 0.82 (0.53–1.04) | 4.16 (3.78–4.66) | 2.07 (1.82–2.23) | 1.56 (1.35–1.79) * | ||
| case | CC | 87 (42.6) | 1.10 (0.75–1.90) | 3.85 (3.08–4.44) | 1.96 (1.39–2.54) | 0.95 (0.87–1.00) | |
| CT | 96 (47.1) | 1.13 (0.81–1.57) | 3.59 (2.84–4.13) | 1.88 (1.44–2.38) | 0.95 (0.84–0.98) | ||
| TT | 21 (10.3) | 1.13 (0.78–2.32) | 3.64 (3.05–4.99) | 2.17 (1.66–2.80) | 0.96 (0.84–1.00) | ||
| rs2230806 | control | AA | 20 (9.7) | 0.81 (0.51–1.24) | 4.33 (3.58–4.66) | 1.94 (1.76–2.36) | 1.36 (1.25–1.57) |
| AG | 89 (43.0) | 0.84 (0.66–1.39) | 4.20 (3.64–4.84) | 2.16 (1.66–2.73) | 1.43 (1.30–1.63) | ||
| GG | 98 (47.3) | 0.83 (0.62–1.12) | 4.16 (3.54–4.77) | 2.01 (1.65–2.57) | 1.46 (1.33–1.65) | ||
| case | AA | 44 (21.6) | 1.09 (0.88–1.40) | 3.59 (3.08–4.21) | 1.89 (1.48–2.38) | 0.95 (0.86–0.99) | |
| AG | 98 (48.0) | 1.11 (0.71–1.77) | 3.68 (2.88–4.31) | 1.90 (1.42–2.57) | 0.95 (0.84–1.00) | ||
| GG | 62 (30.4) | 1.39 (0.78–2.06) | 3.91 (2.84–4.54) | 1.98 (1.42–2.41) | 0.95 (0.85–0.99) | ||
| rs1800976 | control | CC | 41 (19.8) | 0.84 (0.63–1.42) | 4.28 (3.38–4.79) | 1.90 (1.54–2.79) | 1.36 (1.28–1.85) |
| CG | 114 (55.1) | 0.84 (0.58–1.27) | 4.28 (3.80–4.70) | 2.11 (1.71–2.64) | 1.43 (1.32–1.59) | ||
| GG | 52 (25.1) | 0.80 (0.58–1.06) | 4.01 (3.43–4.77) | 1.96 (1.55–2.44) | 1.46 (1.31–1.67) | ||
| case | CC | 50 (24.5) | 1.29 (0.81–2.04) | 3.84 (2.97–4.92) | 1.82 (1.44–2.65) | 0.96 (0.85–1.00) | |
| CG | 91 (44.6) | 0.94 (0.73–1.41) * | 3.63 (3.06–4.21) | 1.91 (1.46–2.38) | 0.93 (0.84–0.99) | ||
| GG | 63 (30.9) | 1.25 (0.88–2.17) * | 3.70 (2.85–4.52) | 1.96 (1.38–2.56) | 0.95 (0.86–0.99) | ||
| rs4149313 | control | AA | 99 (47.8) | 0.83 (0.62–1.32) | 4.23 (3.48–4.93) | 2.00 (1.53–2.73) | 1.48 (1.31–1.67) |
| AG | 84 (40.6) | 0.84 (0.64–1.30) | 4.18 (3.71–4.78) | 2.15 (1.77–2.64) | 1.40 (1.31–1.58) | ||
| GG | 24 (11.6) | 0.77 (0.56–1.15) | 4.04 (3.69–4.45) | 1.89 (1.70–2.27) | 1.38 (1.30–1.48) | ||
| case | AA | 64 (31.4) | 1.46 (1.01–2.42) * | 3.92 (3.16–4.64) * | 2.07 (1.66–2.54) * | 0.93 (0.84–0.99) | |
| AG | 94 (46.1) | 1.06 (0.70–1.46) * | 3.63 (2.74–4.21) * | 1.81 (1.36–2.40) * | 0.96 (0.85–0.99) | ||
| GG | 46 (22.5) | 1.00 (0.77–1.71) * | 3.55 (2.72–4.18) | 1.91 (1.36–2.43) | 0.94 (0.88–1.00) |
Note: * p < 0.05, TG, triglyceride; TC, total cholesterol; LDL-C, low-density lipoprotein-cholesterol; HDL-C, high-density lipoprotein-cholesterol.