Table 1.
Pharmacokinetic Parameters for LSD and O-H-LSD
| N= | Cmax (ng/ml) Geometric Mean (95%CI) | tmax (h) Median (range) | t1/2 (h) Tmax-12h Mean±SD | t1/2 (h) Terminal Mean±SD | AUC24 (ng·h/ mL) Geometric Mean (90%CI) | AUC∞ (ng·h/ mL) Geometric Mean (90%CI) | CLR (mL/min) Mean±SD | ||
|---|---|---|---|---|---|---|---|---|---|
| LSD | All | 16 | 4.3 (3.8–4.9) | 1.5 (0.5–4) | 3.6±0.9 | 8.9±5.9 | 26 (22–30) | 28 (24–33) | 79±36 |
| LSD | Male | 8 | 4.4 (3.6–5.3) | 1.5 (0.5–4) | 3.5±1.0 | 10.2±6.7 | 25 (18–35) | 28 (20–38) | 88±36 |
| LSD | Female | 8 | 4.2 (3.4–5.3) | 1.5 (0.5–3) | 3.8±0.8 | 7.6±5.1 | 26 (23–30) | 28 (25–32) | 71±36 |
| aO-H-LSD | All | 8 | 0.4 (0.3–0.5) | 4 (2.5–6) | 3.4 (2.6–4.3) | 3.8 (2.8–5.3) |
Abbreviations: AUC, area under the plasma concentration-time curv; AUC∞, AUC from time zero to infinity; AUC24, from time 0–24; CLR, renal clearance; Cmax, maximum observed plasma concentration; T1/2, plasma half-life; Tmax, time to reach Cmax; aO-H-LSD levels were above the limit of detection in only 8 subjects).