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. 2016 Mar 1;13:17. doi: 10.1186/s12986-016-0075-0

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© Ghosh et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Venn diagrams of differentially expressed genes affected by diet and genotype along with two-way Ward clustering of top 5 increased and top 5 decreased genes. Legend: a Overlap among significantly differentially expressed (DE) genes from each treatment (genotype, diet). Genes with an absolute fold change ≥ 1.5-fold and a nominal p-value <0.01 were considered to be significantly DE. b Two-way Ward clustering of top significantly DE genes. Treatments are organized by columns and genes by rows (expression levels in the heatmap are color-coded with blue representing lower and red representing higher levels of mRNA abundance). J, BALB/cByJ or Acads−/−; KZ, BALB/ByKZ, or Acads+/+