Fig. 1.

Mutation frequency and mutation spectrum of AYA cancers. a Somatic mutation frequencies of pediatric, AYA and adult cancers are shown. Mutation frequencies of AYA cancers were assessed using somatic mutations annotated as nonsynonymous SNVs, synonymous SNVs, nonsense mutations, stop-loss mutations, splicing mutations, frameshift indels, in-frame indels, and noncoding RNA. Mutation frequencies for other cancers were derived from published data from the same regions [19]. b The mutation spectrum of AYA cancers (transition and transversion frequency) was assessed using SNVs processed with MuTect in whole-exome regions