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. 2016 Feb 29;16:170. doi: 10.1186/s12885-016-2209-1

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© Cha et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Candidate driving genetic alterations and their druggability in AYA cancers. An analysis of WES/WTS and OncoScan™ with our heuristic annotation identified level-1 candidate genetic alterations. By analyzing DAVID and DGIdb, the representative pathway of AYA cancers and druggability were also identified. The druggability is indicated by illustrations of pills; red indicates a direct inhibitor of a candidate target gene, and blue/yellow indicates an inhibitor of a pathway that includes the candidate alterations. AYA07 was excluded from the candidate gene search due to the hypermutation. All candidate genetic alterations are described in Additional file 4: Table S3