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. 2016 Mar;147(3):229–241. doi: 10.1085/jgp.201511517

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© 2016 Corbin-Leftwich et al.

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Figure 1. — K⁺ deactivation rate decreases as a function of activation. (A) K⁺ currents recorded from Xenopus oocytes coexpressing human K_V7.2 and K_V7.3 channels using the cut-open voltage-clamp technique. Test pulses ranging from −120 mV to +60 mV were applied from an HP of −90 mV. Deactivation of the current was driven at −105 mV (arrow). (B) Normalized deactivating currents from activating pulses from −30 to +60 mV. Deactivation slowed down after higher activating potentials. (C) Deactivation time constant (τ_DEACT) versus test pulse potential (τ_DEACT–V_PULSE) plot. Error bars represent standard deviation. (D) Kinetics scheme describing alternative pathways for the deactivation of the heteromeric K_V7.2/K_V7.3 channel. Voltage-dependent transitions are noted with V.