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. 2016 Mar;147(3):229–241. doi: 10.1085/jgp.201511517

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© 2016 Corbin-Leftwich et al.

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Figure 3. — Deactivation time constant increase as a function of the duration of the activating pulse. (A and B) K⁺ currents were activated by 40-mV pulses with a duration varying from 10 to 4,175 ms in the absence (A) and presence (B) of 1-µM Retigabine. The duration of the pulse increased 1.3-fold for each trace. After activation, the K⁺ current was deactivated at −90 mV. (C) τ_DEACT–t_PULSE plot shows that τ_DEACT increased as the activating pulse was longer (black squares). In the presence of Retigabine, τ_DEACT increased further. (D) The same plot as in C, but the t_PULSE is displayed in a logarithmic scale to highlight the τ_DEACT–t_PULSE relationship for shorter activating pulses and showing that τ_DEACT was unaltered by Retigabine for pulses shorter than 500 ms. Error bars represent standard deviation. Control, n = 7; Retigabine, n = 6.