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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cancer Cell. 2015 Nov 9;28(5):548–549. doi: 10.1016/j.ccell.2015.10.011

Figure 1. Glucose-induced activation of SREBP and lipogenesis.

Figure 1

Glucose promotes lipogenesis by (1) generating acetyl-CoA, the substrate for lipogenesis, (2) stimulating pancreatic insulin secretion, which activates SREBP-dependent lipogenic gene expression, and (3) generating UDP-GlcNAc required for SCAP N-glycosylation. Glycosylation of SCAP prevents its degradation and promotes disassociation from the ER-reside protein INSIG, resulting in SREBP activation. Abbreviations are as follows: insulin-induced gene, INSIG; uridine diphosphate N-acetylglucosamine, UDP-GlcNAc; acetyl coenzyme A, acetyl-CoA.