Table 2.
Univariate and multivariate Cox proportional regression analysis of factors associated with recurrence
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95 % CI) | P | HR (95 % CI) | P | |
| Age (> 50yvs. ≤ 50y) | 0.90 (0.55–1.48) | 0.673 | N.A. | N.A. |
| Sex (male vs. female) | 1.01 (0.48–2.10) | 0.990 | N.A. | N.A. |
| HBsAg (Positive vs. Negative) | 0.77 (0.33–1.77) | 0.536 | N.A. | N.A. |
| Child-Pugh score (A vs. B) | 1.12 (0.27–4.55) | 0.879 | N.A. | N.A. |
| Liver cirrhosis (Yes vs. No) | 0.99 (0.45–2.16) | 0.977 | N.A. | N.A. |
| AFP (> 400 ng/ml vs. ≤ 400 ng/ml) | 1.73 (1.06–2.81) | 0.027 | 1.30 (0.78–2.16) | 0.309 |
| Tumor number (Multiple vs. Single) | 1.77 (1.04–3.00) | 0.022 | 1.42 (0.82–2.48) | 0.214 |
| Tumor size (> 5 cm vs. ≤ 5 cm) | 1.35 (0.79–2.31) | 0.273 | N.A. | N.A. |
| Vascular invasion (Yes vs. No) | 2.16 (1.34–3.48) | 0.002 | 1.14 (0.68–1.93) | 0.621 |
| Satellite lesion (Yes vs.No) | 2.92 (1.66–5.16) | 0.001 | 1.96 (1.06–3.63) | 0.032 |
| Tumor encapsulation (Yes vs. No) | 2.26 (1.40–3.63) | 0.001 | 1.64 (0.99–2.71) | 0.054 |
| Edmondson stage (III-IV vs. I-II) | 2.15 (1.31–3.52) | 0.003 | 1.75 (1.05–2.93) | 0.032 |
| CD146 (High vs. LOW) | 3.64 (2.20–6.03) | <0.001 | 2.49 (2.43–4.00) | 0.001 |
Abbreviations: HBsAg Hepatitis B surface antigen, AFP α-fetoprotein