Table 2.
Drug interaction between cisplatin and BMS-754807
| Cell line | Cisplatin (μM) | BMS-754807 (µM) | Interactiona |
|---|---|---|---|
| A549 | 0.5 | 0.01 | Synergistic |
| A549 | 1.0 | 0.01 | Synergistic |
| A549 | 2.5 | 0.01 | Synergistic |
| A549 | 0.5 | 0.1 | Synergistic |
| A549 | 1.0 | 0.1 | Synergistic |
| A549 | 2.5 | 0.1 | Synergistic |
| A549 | 0.5 | 0.25 | Synergistic |
| A549 | 1.0 | 0.25 | Synergistic |
| A549 | 2.5 | 0.25 | Synergistic |
| NCI-H358 | 2.5 | 0.001 | Antagonistic |
| NCI-H358 | 5.0 | 0.001 | Antagonistic |
| NCI-H358 | 7.5 | 0.001 | Antagonistic |
| NCI-H358 | 2.5 | 0.1 | Additive |
| NCI-H358 | 5.0 | 0.1 | Additive |
| NCI-H358 | 7.5 | 0.1 | Additive |
| NCI-H358 | 2.5 | 0.25 | Antagonistic |
| NCI-H358 | 5.0 | 0.25 | Additive |
| NCI-H358 | 7.5 | 0.25 | Additive |
aCombination index <1 = synergistic interaction, combinations index ~1
= additive interaction, combination index >1 = antagonistic interaction