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. 2016 Mar 1;8:36. doi: 10.3389/fnagi.2016.00036

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Copyright © 2016 Hoss, Labadorf, Beach, Latourelle and Myers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNA profile for Parkinson's disease with dementia. (A) Line plot for the 125 DE miRNAs in PD. The counts were scaled using Z-transformation, and the means were calculated for each miRNA for each condition (control, PDN, PDD). The line colors correspond to the beta estimates from the ordinal regression analysis, where blue=negative ordered relationship and red=positive ordered relationship. (B) PDN/PDD class prediction, using the 36 nominally significant miRNAs from PDN/PDD differential expression analysis. Four errors were observed among the 29 samples studied which may reflect heterogeneity in the etiology of PD.