Table 3.

Treatment of OP exposed mice with oxime TAB2OH. The oxime was administered either alone (Therapy: i.m. 25 mg/kg with atropine 1 min after an OP) or as combination with hBChE (Pretreatment + Therapy: i.v. [hBChE (1 mg/kg) + TAB2OH (25 mg/kg)] 15 min before OP followed by TAB2OH (25 mg/kg with atropine) administered i.m. 1 min after an OP). Protective Index is the ratio of LD₅₀ for OP exposed animals with pretreatment/therapy and animals exposed to OP only. In parentheses 95% confident limits of protective index and MDP (the highest multiple of the OP LD₅₀, which was fully counteracted by the antidotal treatment) are also given.

Treatment	VXa		Paraoxonb		Sarinc		Tabund
	Protective Index (95% conf. limits)	MDP	Protective Index (95% conf. limits)	MDP	Protective Index (95% conf. limits)	MDP	Protective Index (95% conf. limits)	MDP
Therapy	5.0 (2.2–11.7)	3.2	10 (7.5–13.3)	6.3	2.9 (2.3–3.7)	2.0	1.6 (1.2–2.1)	1.3
Pretreatment + Therapy	5.0 (3.3–7.7)	3.2	16 (13.5–18.7)	13	4.0 (2.5–6.4)	2.0	1.3 (1.0–1.6)	1.3

^as.c. LD₅₀ of VX was 28 µg/kg.

^bs.c. LD₅₀ of Paraoxon was 740 µg/kg.

^cs.c. LD₅₀ of Sarin was 240 µg/kg.

^bs.c. LD₅₀ of Tabun was 570 µg/kg.