Table 3.
Transcriptomic alterations of cholesterol and LC-PUFA biosynthesis pathways in distal gut of Atlantic salmon
| Pathway/Gene | Gene fold change relative to fish meal (FM) dieta | |||||
|---|---|---|---|---|---|---|
| S45 | S34B11 | S22B22 | S11B34 | B45 | SBM | |
| Cholesterol biosynthesis | ||||||
| FDFT1, farnesyl-diphosphate farnesyltransferase 1 | 1.8 | 2.9 | ||||
| CYP51A1, cytochrome P450, family 51, subfamily A, polypeptide 1 | 3.1 | 2.3 | 2.6 | |||
| TM7SF2, transmembrane 7 superfamily member 2 | 2.1 | 1.8 | 1.7 | 1.5 | ||
| MSMO1, methylsterol monooxygenase 1 | 2.5 | 2.4 | ||||
| NSDHL, NAD(P) dependent steroid dehydrogenase-like | 2.4 | |||||
| SC5D, sterol-C5-desaturase | 2.5 | 1.9 | 1.9 | |||
| DHCR7, 7-dehydrocholesterol reductase | 1.9 | 1.9 | 2.2 | 1.9 | 1.6 | 1.6 |
| LC-PUFA biosynthesis | ||||||
| ACSBG2, acyl-CoA synthetase bubblegum family member 2 | 15.3 | |||||
| ACSL5, acyl-CoA synthetase long-chain family member 5 | −4.2 | |||||
| ACSL6, acyl-CoA synthetase long-chain family member 6 | −1.6 | |||||
| CYB5A, cytochrome b5 type A (microsomal) | 1.7 | |||||
| CYB5R3, cytochrome b5 reductase 3 | 1.6 | 1.5 | ||||
| FADS2, fatty acid desaturase 2 | 2.1 | 2.0 | 2.4 | |||
| SLC27A2, solute carrier family 27 (fatty acid transporter), member 2 | 1.7 | 1.6 | ||||
S45, S34B11, S22B22, S11B34, B45 and SBM are diets with 45 % of soy protein concentrate (SPC), 34 % SPC and 11 % of bean protein concentrate (BPC), 22 % SPC and 22 % BPC, 11 % SPC and 34 % BPC, 45 % BPC, and enriched with soybean meal (SBM), respectively
aOnly genes considered as differentially expressed (adjusted P-value < 0.2, absolute fold change ≥ 1.4) are reported