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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Connect Tissue Res. 2015;56(4):265–271. doi: 10.3109/03008207.2015.1040547

Figure 1. Diagram of local chondroprogenitor cell activation and differentiation in response to articular cartilage injury in OA.

Figure 1

1) Chondroprogenitors replicate. 2) One of the daughter cells keep the progenitor phenotype while 3) others proliferate and undergo chondrogenesis to become mature chondrocytes. 4) Chondrocytes either terminally differentiate becoming hypertrophic cartilage tissue or dedifferentiate into fibrocartilage.