Table 2.
Comparison of pubertal body weight at puberty in Lin28a GOF, Lin28b LOF, and let-7 GOF male and female mice
| genotype | sex | weight at VO/PS | n |
|---|---|---|---|
| wt | M | 15.4 +/− 1.3 | 33 |
| Lin28a GOF | M | 20.8 +/− 2.1 | 16 |
| p<0.0001 | |||
| wt | F | 15.3 +/− 1.5 | 24 |
| Lin28a GOF | F | 21.1 +/− 2.0 | 15 |
| p<0.0001 | |||
| wt | M | 16.8 +/− 2.0 | 29 |
| Lin28b LOF | M | 16.6 +/− 2.1 | 17 |
| ns | |||
| wt | F | 15.5 +/− 0.8 | 13 |
| Lin28b LOF | F | 14.8 +/− 1.3 | 9 |
| ns | |||
| control | M | 16.5 +/− 1.9 | 12 |
| let-7 GOF | M | 18.2 +/− 2.1 | 15 |
| p=0.03 | |||
| control | F | 15.9 +/− 0.8 | 24 |
| let-7 GOF | F | 15.3 +/− 1.0 | 22 |
| p=0.008 |
VO, vaginal opening. PS, preputial separation. P-values were calculated with the student’s t-test.