Table 2.
Prognostic analyses of all markers for association with OS and PFS
| All patients | KRAS-WT | KRAS-Mut | ||||
|---|---|---|---|---|---|---|
| Gene | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P |
| OS | ||||||
| AREG | 1.01 (0.88–1.15) | 0.923 | 0.97 (0.82–1.16) | 0.760 | 1.07 (0.89–1.30) | 0.475 |
| BTC | 1.01 (0.85–1.21) | 0.903 | 1.05 (0.83–1.34) | 0.678 | 1.01 (0.75–1.35) | 0.963 |
| CD73 | 1.05 (0.91–1.21) | 0.495 | 1.06 (0.88–1.27) | 0.536 | 1.04 (0.83–1.30) | 0.751 |
| DUSP4 | 0.99 (0.86–1.13) | 0.884 | 1.04 (0.89–1.23) | 0.599 | 0.91 (0.70–1.18) | 0.473 |
| EGF | 0.84 (0.68–1.03) | 0.093 | 0.81 (0.63–1.04) | 0.098 | 1.04 (0.61–1.76) | 0.890 |
| EGFR | 1.09 (0.91–1.30) | 0.372 | 1.04 (0.81–1.34) | 0.748 | 1.18 (0.88–1.59) | 0.272 |
| EPGN | 0.86 (0.60–1.23) | 0.399 | 0.96 (0.58–1.59) | 0.871 | 1.00 (0.59–1.68) | 0.988 |
| EREG | 0.94 (0.86–1.03) | 0.212 | 0.87 (0.77–0.98) | 0.017 | 1.07 (0.91–1.25) | 0.405 |
| HBEGF | 0.87 (0.73–1.04) | 0.121 | 0.86 (0.66–1.12) | 0.261 | 0.87 (0.68–1.11) | 0.250 |
| HER2 | 0.78 (0.60–1.02) | 0.071 | 0.83 (0.61–1.14) | 0.246 | 0.72 (0.41–1.28) | 0.264 |
| HER3 | 0.98 (0.81–1.18) | 0.831 | 1.03 (0.81–1.31) | 0.785 | 0.90 (0.64–1.28) | 0.565 |
| HER4 | 0.88 (0.70–1.11) | 0.283 | 0.87 (0.64–1.19) | 0.391 | 0.84 (0.53–1.31) | 0.414 |
| PHLDA1 | 1.06 (0.87–1.29) | 0.567 | 1.06 (0.81–1.38) | 0.679 | 1.21 (0.85–1.72) | 0.299 |
| TGFA | 1.01 (0.83–1.22) | 0.952 | 1.06 (0.85–1.32) | 0.621 | 0.84 (0.54–1.29) | 0.422 |
| PFS | ||||||
| AREG | 0.91 (0.80–1.03) | 0.144 | 0.90 (0.77–1.06) | 0.220 | 0.93 (0.77–1.13) | 0.461 |
| BTC | 0.89 (0.76–1.05) | 0.172 | 0.94 (0.75–1.17) | 0.578 | 0.84 (0.63–1.12) | 0.234 |
| CD73 | 0.99 (0.86–1.14) | 0.910 | 1.02 (0.85–1.22) | 0.866 | 0.97 (0.78–1.21) | 0.799 |
| DUSP4 | 0.95 (0.83–1.08) | 0.412 | 0.98 (0.84–1.15) | 0.799 | 0.89 (0.69–1.14) | 0.360 |
| EGF | 0.89 (0.74–1.07) | 0.223 | 0.86 (0.68–1.09) | 0.202 | 1.16 (0.75–1.80) | 0.492 |
| EGFR | 0.89 (0.73–1.07) | 0.220 | 0.80 (0.58–1.09) | 0.168 | 0.95 (0.73–1.23) | 0.696 |
| EPGN | 0.96 (0.67–1.36) | 0.815 | 1.04 (0.62–1.75) | 0.890 | 1.01 (0.60–1.71) | 0.963 |
| EREG | 0.89 (0.80–0.98) | 0.016 | 0.84 (0.74–0.96) | 0.008 | 0.95 (0.82–1.11) | 0.526 |
| HBEGF | 0.87 (0.73–1.03) | 0.117 | 0.92 (0.71–1.19) | 0.507 | 0.83 (0.66–1.04) | 0.103 |
| HER2 | 0.64 (0.49–0.85) | 0.002 | 0.66 (0.47–0.92) | 0.013 | 0.65 (0.38–1.12) | 0.123 |
| HER3 | 0.87 (0.74–1.04) | 0.127 | 0.91 (0.73–1.14) | 0.425 | 0.80 (0.59–1.10) | 0.174 |
| HER4 | 0.80 (0.62–1.02) | 0.067 | 0.79 (0.56–1.12) | 0.180 | 0.77 (0.50–1.17) | 0.180 |
| PHLDA1 | 0.95 (0.79–1.15) | 0.618 | 0.97 (0.76–1.24) | 0.827 | 1.00 (0.71–1.39) | 0.976 |
| TGFA | 0.90 (0.73–1.12) | 0.359 | 0.95 (0.74–1.23) | 0.704 | 0.81 (0.53–1.22) | 0.306 |