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Increased phagocytosis and splenic uptake of HFD-RBCs. A, RBC phagocytosis by mouse macrophages. B, Representative images of splenic sections showing uptake of labeled RBCs from CD- or HFD-fed mice in vivo: Top, low-power images of the spleen sections; Bottom, high-power images of the boxed areas. The graph is a quantification of RBC splenic uptake (see text for details). n=3 to 4 (1 dot = 1 mouse); *P<0.05. CD indicates chow diet; HFD, high-fat diet; and RBC, red blood cell.
