Effect of nicotine on angiotensin II (Ang II)–induced blood pressure (BP) response in sham, ovariectomy (OVX), and OVX+E2 offspring. Diastolic BP (DBP), systolic BP (SBP), and mean arterial BP (MAP) responses to Ang II (10 µg/kg) were measured in sham, OVX, and OVX+E2 groups of female offspring that had been exposed in utero to saline control or nicotine. All of the data are expressed as means±SEM from 6 animals in each group. †P<0.05 vs saline group; *P<0.05 vs data points in saline group. (Used with permission, Figure 1, 251).