Figure 1.

Schematic diagram detailing the time course of cuprizone, quetiapine, and MW167 treatment. (A) The timeline for experiment 1. All animals were subjected to 1 week of adaptation, and then animals were treated with drugs (eg, cuprizone and/or quetiapine) as indicated for 6 weeks, and subjected to 1 week of behavioral analysis before sacrifice. (B) The timeline for experiment 2. This experiment was carried out as in (A), except that mice from all groups went through lateral ventricular catheterization surgery for intracranial delivery of MW167 or vehicle 5 weeks into the 6-week drug treatment. Mice in the control + MW167 and cuprizone + quetiapine + MW167 group were treated with 2 μL of 1mM MW167 daily during the final week of the drug treatment period. At the end of the experiments described in (A) and (B), animals were sacrificed to assess molecular differences among all groups.