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. 2015 Aug 1;19(2):pyv088. doi: 10.1093/ijnp/pyv088

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Behavioral effects of cuprizone and quetiapine treatment. (A) The cuprizone-treated mice had an inferior prepulse inhibition (PPI), which was reversed by quetiapine treatment (main effect of treatment, F _{3, 92}=3.835, P=.013). (B-C) The cuprizone-treated mice spent less time (F _{3, 20}=4.886, P<.05), travelled a shorter distance (F _{3, 18}=4.212, P<.05) in the central area of the open field test, and exhibited anxiety-like behaviors, which were ameliorated by quetiapine cotreatment. (D) In the Y-maze test, cuprizone-treated mice showed impaired spatial working memory and spatial cognitive ability, which was rescued by quetiapine administration (F _{3, 25}=3.114, P<.05). (E-F) In the 3-chamber test, mice in the cuprizone group showed reduced social interactions and weaker social memory. Mice in the cuprizone + quetiapine group performed better than those treated with cuprizone alone. #P<.05 compared with the control group or the CPZ + Que group; *P<.05, **P<.01, ⁺ P<.05, ⁺⁺ P<.01, compared with the empty wire cup or Stranger 1.