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. 2015 Aug 1;19(2):pyv088. doi: 10.1093/ijnp/pyv088

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Quetiapine protected the forebrain from demyelination. (A) MBP immunofluorescent in the ventral lateral part of the caudoputamen (CPu) and cerebral cortex (CTX) of mice in each group (n=6). (B-C) Histogram represents the quantitative analysis of the integral optical density (IOD) of MBP level in CPu (F _{3, 20} = 33.79, P<.01) and CTX (F _{3, 20}=5.978, P<.01). (D) Western-blot assays demonstrated reduced expression of MBP in the forebrain of cuprizone-treated mice was restored by quetiapine cotreatment (F _{3, 20}=7.084, P<.01). Scale bar A=500 μm. *P<.05, **P<.01.