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. 2015 Aug 1;19(2):pyv088. doi: 10.1093/ijnp/pyv088

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — The antipsychotic effects of quetiapine were inhibited by MW167. (A) MW167 could affect the prepulse inhibition (PPI) and block the increased PPI induced by quetiapine. (B-C) The open field test revealed the anti-anxiety effects of quetiapine were blocked by MW167. (D) The Y-maze test showed quetiapine rescue of working memory deficits was blocked by MW167 injection. (E-F) In the 3-chamber test, mice in the cuprizone (CPZ) group and the CPZ + quetiapine (Que) + MW167 group showed reduced social interactions and weaker social memory. Mice in the cuprizone + quetiapine group performed better than those treated with cuprizone or cuprizone plus MW167. *P<.05, **P<.01; ⁺ P<.05, compared with the empty wire-cup or Stranger 1; # P<.05 compared with CPZ + Que group.