Figure 5.

Tests of anxiety-like behavior. (A) Adeno-associated virus (AAV)-Glu-MAGL mice spent less time in the center in the open field test than AAV-WT controls. (B) Locomotor activity did not differ between the 2 groups in the open field. (C-D) In the elevated plus maze (EPM), time spent in the open arm and entries in the open arm were reduced in AAV-Glu-MAGL. (E-F) Entries and time spent in the aversive lit compartment were reduced in AAV-Glu-MAGL in the light/dark test without reaching statistical significance. n=20–24 mice/group. *P<.05, **P<.01.