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. 2015 Oct 5;19(2):pyv115. doi: 10.1093/ijnp/pyv115

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Effects of intra-ventral tegmental area (VTA) infusion of AG490 on leptin’s anxiolytic effects in the elevated plus-maze test. Mice received an intra-VTA infusion of AG490 (0.15 nmol/side) or vehicle 60 minutes before an i.p. injection of leptin (1mg/kg) or saline. The elevated plus-maze test was performed 30 minutes after leptin injection. (A) Percent open arm entries. (B) Percent open arm time. (C) The number of total entries made into open and closed arms. n = 10 to 14 each group. ***P < .001, compared with the Vehicle+Saline control group; ^## P < .01, compared with the Vehicle+Leptin group. (D) Schematic illustration of bilateral injection sites in the VTA.