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. 2015 Oct 5;19(2):pyv115. doi: 10.1093/ijnp/pyv115

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© The Author 2015. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 7. — Adeno-associated virus (AAV)-Cre–mediated deletion of leptin receptor (LepRb) in the intra-ventral tegmental area (VTA) of adult Lepr^flox/flox mice. (A) Schematic diagram depicting the floxed Lepr allele and the Lepr floxed allele after Cre recombination. (B) Left, schematic illustration of AAV injection (Paxinos and Franklin, 2001). Right, Cre-GFP expression in the VTA. (C) Immunohistochemical staining showing leptin-induced STAT3 phosphorylation in the VTA in AAV-GFP (left) and AAV-Cre-GFP (right) injected mice. IP, interpeduncular nucleus; ML, medial lemniscus; SN, substantia nigra.